Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 36.00 | |
100 mg | In stock | $ 46.00 | |
200 mg | In stock | $ 68.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
Kinase Assay | Kinase inhibition: The ability of compounds to inhibit ATR, ATM or DNAPK kinase activity istested using a radiometric-phosphate incorporation assay. A stock solution isprepared consisting of the appropriate buffer, kinase, and target peptide. To this isadded the compound of interest, at varying concentrations in DMSO to a final DMSO concentration of 7%. Assays are initiated by addition of an appropriate [γ-33P]ATP solution and incubated at 25 ℃. Assays are stopped, after the desired time course, by addition of phosphoric acid and ATP to a final concentration of 100 mM and 0.66 μM, respectively. Peptides are captured on a phosphocellulose membrane, prepared as per manufacturer's instructions, and washed six times with 200 μL of 100 mM phosphoric acid, prior to the addition of 100 μL of scintillation cocktail and scintillation counting on a 1450 Microbeta Liquid Scintillation Counter. Dose?response data are analyzed using GraphPad Prism software |
Synonyms | DOC acetate, Cortexone acetate, 11-Deoxycorticosterone acetate |
Molecular Weight | 372.5 |
Formula | C23H32O4 |
CAS No. | 56-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (24.2 mM)
Ethanol: 6 mg/mL (16.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Deoxycorticosterone acetate 56-47-3 Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Glucocorticoid Receptor Adrenergic Receptor Endogenous Metabolite Deoxycorticosterone 11-Deoxycorticosterone Acetate Inhibitor Cortexone Acetate renal inflammation Deoxycorticosterone Acetate adrenocortin unilateral nephrectomy DOC Mineralocorticoid Receptor DOC Acetate 11-Deoxycorticosterone fibrosis DOC acetate Cortexone acetate Cortexone aldosterone precursor glomerular injury and proteinuria 11-Deoxycorticosterone acetate inhibit inhibitor